Publications

Publications 2026

Ning JF, Davis ZB, Zeb Q, Hinderlie P, Tuininga K, Wang L, Chaudhary S, Vue Y, Ma J, Zhu S, Zhang Y, Seeman ZJ, Malmberg KJ, Valamehr B, Largaespada DA, Zorko N, Felices M, Cichocki F, Miller JS, Chen CC (2026)
Induced pluripotent stem cell-derived natural killer cell therapy induces durable responses in glioblastoma and overcomes resistance via a B7-H3-targeted tri-specific killer engager
Neuro Oncol, 28 (10), 2369-2383
DOI 10.1093/neuonc/noag154, PubMed 42434963

Radulovic M, Pust S, Kournoutis A, Chen D, Giner MI, Liang Q, Phuyal S, Böddeker TJ, McCarron K, Herrmann E, Rose K, Schultz SW, Brech A, Hurley JH, Bussi C, Bonet-Ponce L, Gutierrez MG, Raiborg C, Stenmark H (2026)
DFCP1-containing ER microdomains mediate lysosomal membrane repair
Nat Cell Biol, 28 (10), 2036-2053
DOI 10.1038/s41556-026-02062-z, PubMed 42744858

Drivet E, Tsykunova G, Egner IM, Lund KP, Goll GL, Tran HTT, Holme PA, Tvedt THA, Ghanima W, Munthe LA, Kared H (2026)
Interleukin-17-associated inflammation in non-responders and B-cell remodeling after daratumumab in refractory immune thrombocytopenia
Haematologica (in press)
DOI 10.3324/haematol.2026.301032, PubMed 42687820

Nilsen J, Sand KMK, Al-Khabbaz HJ, van Ligtenberg LM, Mester S, Mathiesen L, Noordzij HT, Jensen KR, Leitzinger N, Ottersen O, Benjakul S, Herigstad ML, Ruso-Julve F, Anthi AK, Moen A, Nyquist-Andersen M, Gjølberg TT, Bertelsen EL, Cameron J, Foss S, Christianson GJ, Schlothauer T, Stuge TB, Knudsen LE, Sandlie I, Roopenian DC, Ahlen MT, Andersen JT (2026)
Fusion of IgG antibodies to albumin inhibits transport across the placenta
Sci Immunol, 11 (122), eaee5151
DOI 10.1126/sciimmunol.aee5151, PubMed 42600043

LaMont C (2026)
Optimal control and the dynamics of ancestral lineages
Genetics, 233 (4)
DOI 10.1093/genetics/iyag122, PubMed 42145082

Knapp LR, Fischer KS, Sosat J, Villena-Ossa JF, Kluge P, Schmiedel D, Kuball J, Dolstra H, Minguet S, Cornu TI, Cathomen T, Alici E, O'Dwyer M, Wels WS, Malmberg KJ, Romee R, Vivier E, Köhl U, Cerwenka A, Ullrich E (2026)
Accelerating Translation of NK Cell Therapies to the Clinic: A European Perspective
Hum Gene Ther, 37 (15-16), 691-701
DOI 10.1177/10430342261468974, PubMed 42544553

Mukhamedova L, Buchta D, Trebichalská Z, Levdansky Y, Moravcová J, Potěšil D, Zdráhal Z, Hrebík D, Nepovímová L, Gjølberg TT, Andersen JT, Nováček J, Füzik T, Plevka P (2026)
Particles of echovirus 18 open to release their genomes in vivo
Proc Natl Acad Sci U S A, 123 (30), e2601182123
DOI 10.1073/pnas.2601182123, PubMed 42475568

Nagel R, Kochavi A, Flem-Karlsen K, Adhikary M, Gal-On Y, Klaoudatou MG, Champagne J, Valcanover L, Palashati H, Nielsen MM, Feng X, Körner PR, Giebel L, Yang W, Velds A, Hoekman L, Bleijerveld OB, van Tellingen O, Olweus J, Agami R (2026)
Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production
Cancer Res, 86 (14), 3480-3501
DOI 10.1158/0008-5472.CAN-25-4773, PubMed 42095547

Lippold S, Chang K, Dürkoop M, Andersen JT, Yang F, Schlothauer T (2026)
Development of single-chain C1q affinity chromatography-mass spectrometry for the glycoform-resolved characterization of low-affinity immunoglobulin G interactions
MAbs, 18 (1), 2687922
DOI 10.1080/19420862.2026.2687922, PubMed 42319121

Tjärnhage E, Våtsveen TK, Raki M, Nemazee D, Farhan H, Munthe L, Grodeland G (2026)
Repurposing ALK inhibitors as influenza and corona virus antivirals targeting lymphocyte tyrosine kinase (LTK)
Virus Res, 370, 199759
DOI 10.1016/j.virusres.2026.199759, PubMed 42263913

Chen P, Le KM, Li W, Hinrichsen F, Liu X, Braathen RS, Mamia N, Szymanska M, Li Z, Trotta L, Almusa H, Mamia K, Glumoff V, Holland P, Anders S, Kalinichenko A, Kaustio M, Seppänen MRJ, Haapaniemi EM, Varjosalo M, Martelius T, Grönholm J, Saarela J (2026)
Homozygous loss-of-function mutation in SIT1 leads to combined immunodeficiency due to dysregulated T-cell receptor signaling
J Allergy Clin Immunol, 158 (2), 582-597
DOI 10.1016/j.jaci.2026.03.030, PubMed 42128181

Zhang W, Brown EL, Usmani A, Earland N, Kang M, Olelewe C, Viswanathan A, Chauhan PS, Steen CB, Jeon HS, Avagyan S, Alahi I, Semenkovich NP, Schwab JC, Sachs CM, Qaium F, Harris PK, Cai Q, Gentles AJ, Knight J, Graham RP, Bacchiocchi A, Lucas PC, Fields RC, Sznol M, Halaban R, Chen DY, Chaudhuri AA, Newman AM (2026)
Non-invasive profiling of the tumour microenvironment with spatial ecotypes
Nature, 654 (8120), 1076-1087
DOI 10.1038/s41586-026-10452-4, PubMed 42092150

Duléry R, Malmberg KJ, Romee R (2026)
CAR-NK Cells in B-cell Lymphoma: A New Frontier toward Accessible and Scalable Cellular Therapy
Blood Cancer Discov, OF1-OF4 (in press)
DOI 10.1158/2643-3230.BCD-26-0086, PubMed 41996826

König M, Holmøy T, Nygaard GO, Riise J, Midtvedt K, Goll GL, Jørgensen KK, Munthe LA, Fevang B, Myhre AE, Trøseid M (2026)
Vaccination of immunosuppressed patients
Tidsskr Nor Laegeforen, 146 (5)
DOI 10.4045/tidsskr.25.0555, PubMed 42012114

Lanuza PM, Malmberg KJ (2026)
A genetic set-point for natural killer cells
Nat Immunol, 27 (4), 645-646
DOI 10.1038/s41590-026-02474-x, PubMed 41840092

Douvlataniotis K, Titov A, Zeun J, Bilici M, Palashati H, Loh W, Rustad EH, Yang W, Tran TT, Lund-Johansen F, Bollineni RC, Kepple JD, Huth LP, Munthe LA, Boxaspen T, Schjesvold F, Waage A, Wagner DL, Bull KR, Hester J, Issa F, Giannakopoulou E, Olweus J (2026)
TCR T cells targeting IgA- and IgG-expressing multiple myeloma
Blood (in press)
DOI 10.1182/blood.2025031897, PubMed 41770814

Gopalakrishnan RP, Ward JM, Greiff V, Braathen R, Hu X, Bajelan L, Quý KL, Munthe L, Huszthy PC, Bogen B (2026)
Idiotype-specific CD4⁺ T cells chronically stimulate autoreactive B cells to develop into B lymphomas in mice
Nat Commun, 17 (1)
DOI 10.1038/s41467-026-69916-w, PubMed 41741475

Tsykunova G, Holme PA, Tran HTT, Frederiksen H, Tjønnfjord E, Munthe LA, Drivet E, Kared H, Sørvoll IH, Ahlen MT, Mahévas M, Michel M, Bussel J, Kuter DJ, Anderson Tvedt TH, Ghanima W (2026)
Safety and efficacy of daratumumab in immune thrombocytopenia
Blood Adv, 10 (1), 143-154
DOI 10.1182/bloodadvances.2025017279, PubMed 40763272

Publications 2025

Chernigovskaya M, Lê Quý K, Stensland M, Singh S, Nelson R, Yilmaz M, Kalogeropoulos K, Sinitcyn P, Patel A, Castellana N, Bonissone S, Foss S, Andersen JT, Sandve GK, Jenkins TP, Noble WS, Nyman TA, Snapkow I, Greiff V (2025)
Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases
Cell Syst, 16 (11), 101449
DOI 10.1016/j.cels.2025.101449, PubMed 41232534

Kang M, Gulati GS, Brown EL, Qi Z, Avagyan S, Armenteros JJA, Gleyzer R, Zhang W, Steen CB, D'Silva JP, Schwab J, Clarke MF, Chaudhuri AA, Newman AM (2025)
Improved reconstruction of single-cell developmental potential with CytoTRACE 2
Nat Methods, 22 (11), 2258-2263
DOI 10.1038/s41592-025-02857-2, PubMed 41145665

Kalinichenko A, Huemer J, Humer T, Haimel M, Svaton M, Socquet-Juglard N, Casoni GP, Prakash C, von der Linde M, Pazmandi J, van de Wetering C, Nunez-Fontarnau J, Kamnev A, Giuliani S, Jaeger MG, Hahn E, Dobner S, Rukavina A, Sylvander E, Seigner J, Rashkova C, Hoeger B, Traxlmayr MW, Lehner M, Bryceson YT, Saarela J, Hannich T, Castanon I, Winter G, Dupré L et al. (2025)
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Sci Immunol, 10 (112), eado3825
DOI 10.1126/sciimmunol.ado3825, PubMed 41105755

Aaen KH, Testa MF, Nilsen J, Tarantino R, Canepari C, Benedusi M, Benjakul S, Nyquist-Andersen M, Herigstad ML, Cantore A, Valacchi G, Sandlie I, Bernardi F, Pinotti M, Branchini A, Andersen JT (2025)
Tailored collagen binding of albumin-fused hyperactive coagulation factor IX dictates in vivo distribution and functional properties
Nat Commun, 16 (1), 8433
DOI 10.1038/s41467-025-62955-9, PubMed 41022699

Pfefferle A, Malmberg KJ (2025)
Rewiring natural killer cells for next-generation cancer therapies
Cancer Cell, 43 (11), 1980-1982
DOI 10.1016/j.ccell.2025.08.007, PubMed 40972573

Eggebø MS, Heinzelbecker J, Palashati H, Chandler N, Tran TT, Li Y, Yang W, Laos M, Blaas I, Rustad EH, Bollineni RC, Delic-Sarac M, Lund-Johansen F, Nielsen MM, Olweus J (2025)
TCR-engineered T cells targeting a shared β-catenin mutation eradicate solid tumors
Nat Immunol, 26 (10), 1726-1736
DOI 10.1038/s41590-025-02252-1, PubMed 40866620

Foldvari Z, Brennan MS, Titov A, Jacobsen SEW, Olweus J (2025)
Targeting the roots of myeloid malignancies with T cell receptors
Nat Rev Cancer, 25 (12), 965-985
DOI 10.1038/s41568-025-00857-0, PubMed 40841587

Mamia K, Kolbeinsdottir S, Labun K, Li Z, Komisarczuk A, Keskitalo S, Reint G, Loe Haugen F, Olaug Lindestad B, Skundberg Jensen S, Gjerdingen TJ, Tuhkala A, Wieczorek Ervik C, Kopcil P, Fatkhutdinov N, Bronken Martinsen KH, Erichsen HC, Szymanska M, Tölö E, Glumoff V, Saarela J, Melbye Michelsen T, Schalin-Jäntti C, Olweus J, Leinonen E, Varjosalo M, Valen E, Hautala T, Enge M, Martelius T et al. (2025)
Precision T cell correction platform for inborn errors of immunity
Mol Ther, 33 (11), 5624-5643
DOI 10.1016/j.ymthe.2025.08.018, PubMed 40808259

Podgorica M, Drivet E, Vestbøstad J, Kvam AK, Wik HS, Munthe L, Schjerven H (2025)
Azaindole 1, a selective Rock1/2 kinase inhibitor, induces G2/M arrest and cell death in B-cell acute lymphoblastic leukemia (B-ALL)
Leuk Lymphoma, 66 (12), 2311-2315
DOI 10.1080/10428194.2025.2536125, PubMed 40728071

Kaustio M, Szymanska M, Li W, Braathen R, Campbell TM, Haugen FL, Dahal-Koirala S, Silventoinen K, Nurmi K, Dinius M, Nowlan K, Hetemäki I, Chen P, Mamia K, Seppänen MRJ, Grönholm J, Kekäläinen E, Haapaniemi EM, Aalto K, Martelius T, Bryceson Y, Eklund KK, Saarela J (2025)
Heterozygous loss of MAP4K1 causes immune dysregulation by amplifying T-cell responses
J Allergy Clin Immunol, 156 (4), 1024-1037
DOI 10.1016/j.jaci.2025.07.010, PubMed 40716650

Våtsveen TK, Giliberto M, Bjornsdottir V, Centonze F, Besse A, Frey Y, Skånland SS, Tveita A, Alirezaylavasani A, Imbery JF, Misund K, Reiterer V, Zahoor M, Driessen C, Besse L, Tasken K, Schjesvold FH, Farhan H, Munthe LA (2025)
Targeting proteostasis in multiple myeloma through inhibition of LTK
Leukemia, 39 (9), 2237-2245
DOI 10.1038/s41375-025-02682-8, PubMed 40634511

Trabjerg E, Nilsen J, Tollefsrud Gjølberg T, Andersen JT, Leitner A, Rand KD (2025)
Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation
Commun Biol, 8 (1), 922
DOI 10.1038/s42003-025-08252-z, PubMed 40506471

Sohlberg E, Malmberg KJ (2025)
The innate power of natural killer cells in cancer therapy
Nat Med, 31 (6), 1755-1756
DOI 10.1038/s41591-025-03712-9, PubMed 40355615

Nilsen J, Aaen KH, Benjakul S, Ruso-Julve F, Greiner TU, Bejan D, Stensland M, Singh S, Schlothauer T, Sandlie I, Andersen JT (2025)
Enhanced plasma half-life and efficacy of engineered human albumin-fused GLP-1 despite enzymatic cleavage of its C-terminal end
Commun Biol, 8 (1), 810
DOI 10.1038/s42003-025-08249-8, PubMed 40419755

Fjørtoft MO, Garred Ø, Lingjærde OC, Lande KT, Ottestad L, Bergheim IR, OSBREAC, Lømo J, LaMont C, Myklebust JH, Russnes H, Huse K, Rye IH (2025)
Single-cell analysis reveals tumour size as a key driver of immune cell profile alterations in primary breast tumours and corresponding lymph nodes
BJC Rep, 3 (1), 35
DOI 10.1038/s44276-025-00152-3, PubMed 40394379

Gelli HP, Vazquez-Uribe R, Buckley ST, Andersen JT, Alexander Sommer MO (2025)
Advanced microbiome therapeutics for oral delivery of peptides and proteins: Advances, challenges, and opportunities
Adv Drug Deliv Rev, 222, 115603
DOI 10.1016/j.addr.2025.115603, PubMed 40349728

Rosenberger L, Hansmann L, Anastasopoulou V, Wolf SP, Drousch K, Moewes C, Feng X, Cao G, Huang J, Yew PY, Strønen E, Kato T, Saligrama N, Olweus J, Nakamura Y, Willimsky G, Blankenstein T, Schreiber H, Leisegang M (2025)
Selection of therapeutically effective T-cell receptors from the diverse tumor-bearing repertoire
J Immunother Cancer, 13 (5)
DOI 10.1136/jitc-2024-011351, PubMed 40316304

Anthi AK, Kolderup A, Vaage EB, Bern M, Benjakul S, Tjärnhage E, Ruso-Julve F, Jensen KR, Lode HE, Vaysburd M, Nilsen J, Herigstad ML, Sakya SA, Tietze L, Pilati D, Nyquist-Andersen M, Dürkoop M, Gjølberg TT, Peng L, Foss S, Moe MC, Low BE, Wiles MV, Nemazee D, Jahnsen FL, Vaage JT, Howard KA, Sandlie I, James LC, Grødeland G et al. (2025)
An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models
Nat Commun, 16 (1), 3999
DOI 10.1038/s41467-025-59353-6, PubMed 40312392

Gherardini L, Sharma A, Taranta M, Cinti C (2025)
Epigenetic Reprogramming by Decitabine in Retinoblastoma
Front Biosci (Landmark Ed), 30 (4), 33386
DOI 10.31083/FBL33386, PubMed 40302340

Pilati D, Agyei EK, Elkhashab M, Fuchs E, Nielsen IH, Bjerg TW, Anthi AK, Jiménez-Reinoso A, Iversen MB, Pohl L, Narita R, Frago S, Jakobsen MR, Andersen JT, Degn SE, Paludan SR, Alvarez-Vallina L, Howard KA (2025)
Exploiting FcRn engagement of an albumin-CpG oligonucleotide covalent conjugate for potent TLR9 immune induction
J Biol Chem, 301 (6), 108508
DOI 10.1016/j.jbc.2025.108508, PubMed 40222546

Gjølberg TT, Mester S, Calamera G, Telstad JS, Sandlie I, Andersen JT (2025)
Targeting the Neonatal Fc Receptor in Autoimmune Diseases: Pipeline and Progress
BioDrugs, 39 (3), 373-409
DOI 10.1007/s40259-025-00708-2, PubMed 40156757

Weller C, Bartok O, McGinnis CS, Palashati H, Chang TG, Malko D, Shmueli MD, Nagao A, Hayoun D, Murayama A, Sakaguchi Y, Poulis P, Khatib A, Erlanger Avigdor B, Gordon S, Cohen Shvefel S, Zemanek MJ, Nielsen MM, Boura-Halfon S, Sagie S, Gumpert N, Yang W, Alexeev D, Kyriakidou P, Yao W, Zerbib M, Greenberg P, Benedek G, Litchfield K, Petrovich-Kopitman E et al. (2025)
Translation dysregulation in cancer as a source for targetable antigens
Cancer Cell, 43 (5), 823-840.e18
DOI 10.1016/j.ccell.2025.03.003, PubMed 40154482

Rea A, Santana-Hernández S, Villanueva J, Sanvicente-García M, Cabo M, Suarez-Olmos J, Quimis F, Qin M, Llorens E, Blasco-Benito S, Torralba-Raga L, Perez L, Bhattarai B, Alari-Pahissa E, Georgoudaki AM, Balaguer F, Juan M, Pardo J, Celià-Terrassa T, Rovira A, Möker N, Zhang C, Colonna M, Spanholtz J, Malmberg KJ, Montagut C, Albanell J, Güell M, López-Botet M, Muntasell A (2025)
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression
Nat Immunol, 26 (4), 582-594
DOI 10.1038/s41590-025-02103-z, PubMed 40119192

Torralba-Raga L, Malmberg KJ (2025)
The NKG2/HLA-E Axis Influence Outcomes of Haploidentical Transplantation
Transplant Cell Ther, 31 (3), 118-120
DOI 10.1016/j.jtct.2025.02.008, PubMed 40023657

Mester S, Chan C, Lustig M, Foss S, Jansen JHM, Leangen Herigstad M, Evers M, Nilsen J, Reiding KR, A Damen JM, Burger R, Grevys A, Dalhus B, Valerius T, Sandlie I, Leusen JHW, Andersen JT (2025)
Engineering of anticancer human immunoglobulin A equipped with albumin for enhanced plasma half-life
PNAS Nexus, 4 (2), pgaf042
DOI 10.1093/pnasnexus/pgaf042, PubMed 40041621

Champagne J, Nielsen MM, Feng X, Montenegro Navarro J, Pataskar A, Voogd R, Giebel L, Nagel R, Berenst N, Fumagalli A, Kochavi A, Lovecchio D, Valcanover L, Malka Y, Yang W, Laos M, Li Y, Proost N, van de Ven M, van Tellingen O, Bleijerveld OB, Haanen JBAG, Olweus J, Agami R (2025)
Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation
Immunity, 58 (1), 247-262.e9
DOI 10.1016/j.immuni.2024.12.004, PubMed 39755122

Publications 2024

Kared H, Tan C, Narang V, Tan SW, Xian CH, Wei ATS, Lum J, Ruiz-Mateos E, Rajasuriar R, Kamarulzaman A, Ng TP, Larbi A (2024)
SLAMF7 defines subsets of human effector CD8 T cells
Sci Rep, 14 (1), 30779
DOI 10.1038/s41598-024-80971-5, PubMed 39730488

Viermyr HK, Tonby K, Ponzi E, Trouillet-Assant S, Poissy J, Arribas JR, Dyon-Tafani V, Bouscambert-Duchamp M, Assoumou L, Halvorsen B, Tekin NB, Diallo A, De Gastines L, Munthe LA, Murphy SL, Ueland T, Michelsen AE, Lund-Johansen F, Aukrust P, Mootien J, Dervieux B, Zerbib Y, Richard JC, Prével R, Malvy D, Timsit JF, Peiffer-Smadja N, Roux D, Piroth L, Ait-Oufella H et al. (2024)
Safety of baricitinib in vaccinated patients with severe and critical COVID-19 sub study of the randomised Bari-SolidAct trial
EBioMedicine, 111, 105511
DOI 10.1016/j.ebiom.2024.105511, PubMed 39731852

Alirezaylavasani A, Egner IM, Dahl B, Chopra A, de Matos Kasahara T, Goll GL, Jahnsen J, Grødeland G, Vaage JT, Lund-Johansen F, Holter JC, Halvorsen B, Jørgensen KK, Munthe LA, Kared H (2024)
Deficient SARS-CoV-2 hybrid immunity during inflammatory bowel disease
Clin Immunol, 271, 110404
DOI 10.1016/j.clim.2024.110404, PubMed 39645159

Ma J, Meyer S, Olweus J, Jin C, Yu D (2024)
An adjusted droplet digital PCR assay for quantification of vector copy number in CAR-T cell and TCR-T cell products
Immunooncol Technol, 25, 101031
DOI 10.1016/j.iotech.2024.101031, PubMed 40236328

Lustig M, Hahn C, Leangen Herigstad M, Andersen JT, Leusen JHW, Burger R, Valerius T (2024)
Sialylation inhibition improves macrophage mediated tumor cell phagocytosis of breast cancer cells triggered by therapeutic antibodies of different isotypes
Front Oncol, 14, 1488668
DOI 10.3389/fonc.2024.1488668, PubMed 39659795

Behsen AD, Holien T, Micci F, Rye M, Rasmussen JM, Andersen K, Hess ES, Børset M, Keats J, Våtsveen TK, Misund K (2024)
Cell surface marker heterogeneity in human myeloma cell lines for modeling of disease and therapy
Sci Rep, 14 (1), 28805
DOI 10.1038/s41598-024-80263-y, PubMed 39567630

Ørbo HS, de Matos Kasahara T, Wolf AS, Bjørlykke KH, Sexton J, Jyssum I, Tveter AT, Solum G, Kjønstad IF, Bhandari S, Christensen IE, Kvien TK, Lind A, Kared H, Jahnsen J, Haavardsholm EA, Munthe LA, Provan SA, Vaage JT, Mjaaland S, Syversen SW, Jørgensen KK, Grødeland G, Goll GL (2024)
Humoral and cellular responses to a fifth bivalent SARS-CoV-2 vaccine dose in patients with immune-mediated inflammatory diseases on tumour necrosis factor inhibitors: a prospective cohort study
Lancet Reg Health Eur, 48, 101121
DOI 10.1016/j.lanepe.2024.101121, PubMed 39624496

Weiss L, Schluck M, Classens R, de Jonge PKJD, van der Waart A, Nguyen KG, Nguyen TT, Zaharoff DA, Malmberg KJ, Dolstra H, Figdor CG, Sohlberg E, Hammink R (2024)
Interleukin-12 decorated nanosized semiflexible Immunofilaments enable directed targeting and augmented IFNγ responses of natural killer cells
Acta Biomater, 191, 386-397
DOI 10.1016/j.actbio.2024.11.012, PubMed 39528061

Palacios D, Majhi RK, Szabo EK, Clement D, Lachota M, Netskar H, Penna L, Krokeide SZ, Vincenti M, Kveberg L, Malmberg KJ (2024)
The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration
J Immunol, 213 (9), 1349-1357
DOI 10.4049/jimmunol.2400228, PubMed 39320215

Strunz B, Momayyezi P, Bilev E, Muvva JR, Chen P, Bister J, Schaffer M, Akber M, Cornillet M, Karolinska KI/K COVID-19 Study Group, Horowitz A, Malmberg KJ, Rooyackers O, Aleman S, Ljunggren HG, Björkström NK, Strålin K, Hammer Q (2024)
The HLA-B -21 M/T dimorphism associates with disease severity in COVID-19
Genes Immun, 26 (1), 70-74
DOI 10.1038/s41435-024-00302-6, PubMed 39487235

Sætersmoen M, Kotchetkov IS, Torralba-Raga L, Mansilla-Soto J, Sohlberg E, Krokeide SZ, Hammer Q, Sadelain M, Malmberg KJ (2024)
Targeting HLA-E-overexpressing cancers with a NKG2A/C switch receptor
Med, 6 (2), 100521
DOI 10.1016/j.medj.2024.09.010, PubMed 39423821

Alirezaylavasani A, Skeie LG, Egner IM, Chopra A, Dahl TB, Prebensen C, Vaage JT, Halvorsen B, Lund-Johansen F, Tonby K, Reikvam DH, Stiksrud B, Holter JC, Dyrhol-Riise AM, Munthe LA, Kared H (2024)
Vaccine responses and hybrid immunity in people living with HIV after SARS-CoV-2 breakthrough infections
NPJ Vaccines, 9 (1), 185
DOI 10.1038/s41541-024-00972-3, PubMed 39384763

Wolf AS, Bjørlykke KH, Ørbo HS, Bhandari S, Solum G, Kjønstad IF, Jyssum I, Nygaard UC, Kristoffersen AB, Christensen IE, Josefsson SE, Lund KP, Chopra A, Osen JR, Chaban V, Tveter AT, Sexton J, Kvien TK, Jahnsen J, Haavardsholm EA, Grødeland G, Vaage JT, Provan SA, Kared H, Lund-Johansen F, Munthe LA, Syversen SW, Goll GL, Jørgensen KK, Mjaaland S (2024)
T cell responses to repeated SARS-CoV-2 vaccination and breakthrough infections in patients on TNF inhibitor treatment: a prospective cohort study
EBioMedicine, 108, 105317
DOI 10.1016/j.ebiom.2024.105317, PubMed 39260039

Meriranta L, Sorri S, Huse K, Liu X, Spasevska I, Zafar S, Chowdhury I, Dufva O, Sahlberg E, Tandarić L, Karjalainen-Lindsberg ML, Hyytiäinen M, Varjosalo M, Myklebust JH, Leppä S (2024)
Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma
Blood Cancer Discov, 5 (5), 331-352
DOI 10.1158/2643-3230.BCD-23-0182, PubMed 38630892

Bai B, Wise JF, Vodák D, Nakken S, Sharma A, Blaker YN, Brodtkorb M, Hilden V, Trøen G, Ren W, Lorenz S, Lawrence MS, Myklebost O, Kimby E, Pan-Hammarström Q, Steen CB, Meza-Zepeda LA, Beiske K, Smeland EB, Hovig E, Lingjærde OC, Holte H, Myklebust JH (2024)
Multi-omics profiling of longitudinal samples reveals early genomic changes in follicular lymphoma
Blood Cancer J, 14 (1), 147
DOI 10.1038/s41408-024-01124-5, PubMed 39191762

Tulika T, Ruso-Julve F, Ahmadi S, Ljungars A, Rivera-de-Torre E, Wade J, Fernández-Quintero ML, Jenkins TP, Belfakir SB, Ross GMS, Boyens-Thiele L, Buell AK, Sakya SA, Sørensen CV, Bohn MF, Ledsgaard L, Voldborg BG, Francavilla C, Schlothauer T, Lomonte B, Andersen JT, Laustsen AH (2024)
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Structure, 32 (9), 1404-1418.e7
DOI 10.1016/j.str.2024.07.014, PubMed 39146931

Bashour H, Smorodina E, Pariset M, Zhong J, Akbar R, Chernigovskaya M, Lê Quý K, Snapkow I, Rawat P, Krawczyk K, Sandve GK, Gutierrez-Marcos J, Gutierrez DN, Andersen JT, Greiff V (2024)
Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability
Commun Biol, 7 (1), 922
DOI 10.1038/s42003-024-06561-3, PubMed 39085379

Spildrejorde M, Leithaug M, Samara A, Aass HCD, Sharma A, Acharya G, Nordeng H, Gervin K, Lyle R (2024)
Citalopram exposure of hESCs during neuronal differentiation identifies dysregulated genes involved in neurodevelopment and depression
Front Cell Dev Biol, 12, 1428538
DOI 10.3389/fcell.2024.1428538, PubMed 39055655

Hammer Q, Perica K, Mbofung RM, van Ooijen H, Martin KE, Momayyezi P, Varady E, Pan Y, Jelcic M, Groff B, Abujarour R, Krokeide SZ, Lee T, Williams A, Goodridge JP, Valamehr B, Önfelt B, Sadelain M, Malmberg KJ (2024)
Genetic ablation of adhesion ligands mitigates rejection of allogeneic cellular immunotherapies
Cell Stem Cell, 31 (9), 1376-1386.e8
DOI 10.1016/j.stem.2024.06.011, PubMed 38981470

Rebuffet L, Melsen JE, Escalière B, Basurto-Lozada D, Bhandoola A, Björkström NK, Bryceson YT, Castriconi R, Cichocki F, Colonna M, Davis DM, Diefenbach A, Ding Y, Haniffa M, Horowitz A, Lanier LL, Malmberg KJ, Miller JS, Moretta L, Narni-Mancinelli E, O'Neill LAJ, Romagnani C, Ryan DG, Sivori S, Sun D, Vagne C, Vivier E (2024)
High-dimensional single-cell analysis of human natural killer cell heterogeneity
Nat Immunol, 25 (8), 1474-1488
DOI 10.1038/s41590-024-01883-0, PubMed 38956378

Netskar H, Pfefferle A, Goodridge JP, Sohlberg E, Dufva O, Teichmann SA, Brownlie D, Michaëlsson J, Marquardt N, Clancy T, Horowitz A, Malmberg KJ (2024)
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Nat Immunol, 25 (8), 1445-1459
DOI 10.1038/s41590-024-01884-z, PubMed 38956379

Imbery JF, Wiik C, Heinzelbecker J, Jebsen JK, Dobbing MK, Bottini N, Stanford SM, Munthe LA, Tjønnfjord GE, Tveita A, Szodoray P, Nakken B (2024)
CD38 regulates chronic lymphocytic leukemia proliferation via CD45 phosphatase activity
Mol Ther Oncol, 32 (3), 200841
DOI 10.1016/j.omton.2024.200841, PubMed 39474602

Wüsthoff LEC, Lund-Johansen F, Henriksen K, Wildendahl G, Jacobsen JA, Gomes L, Anjum HS, Barlinn R, Kran AB, Munthe LA, Vaage JT (2024)
Seroprevalence of SARS-CoV-2 and humoral immune responses to COVID-19 mRNA vaccines among people who use drugs - in the light of tailored mitigating strategies
Harm Reduct J, 21 (1), 120
DOI 10.1186/s12954-024-01023-9, PubMed 38890611

Pfefferle A, Phuyal S, Netskar H, Malmberg KJ (2024)
Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer
EMBO J, 43 (13), 2527-2529
DOI 10.1038/s44318-024-00144-y, PubMed 38886578

Vo DN, Yuan O, Kanaya M, Telliam-Dushime G, Li H, Kotova O, Caglar E, Honnens de Lichtenberg K, Rahman SH, Soneji S, Scheding S, Bryder D, Malmberg KJ, Sitnicka E (2024)
A temporal developmental map separates human NK cells from noncytotoxic ILCs through clonal and single-cell analysis
Blood Adv, 8 (11), 2933-2951
DOI 10.1182/bloodadvances.2023011909, PubMed 38484189

Otterlei Fjørtoft M, Huse K, Rye IH (2024)
The Tumor Immune Microenvironment in Breast Cancer Progression
Acta Oncol, 63, 359-367
DOI 10.2340/1651-226X.2024.33008, PubMed 38779867

Ask EH, Tschan-Plessl A, Hoel HJ, Kolstad A, Holte H, Malmberg KJ (2024)
MetaGate: Interactive analysis of high-dimensional cytometry data with metadata integration
Patterns (N Y), 5 (7), 100989
DOI 10.1016/j.patter.2024.100989, PubMed 39081571

Martin KE, Hammer Q, Perica K, Sadelain M, Malmberg KJ (2024)
Engineering immune-evasive allogeneic cellular immunotherapies
Nat Rev Immunol, 24 (9), 680-693
DOI 10.1038/s41577-024-01022-8, PubMed 38658708

Chauhan SK, Dunn C, Andresen NK, Røssevold AH, Skorstad G, Sike A, Gilje B, Raj SX, Huse K, Naume B, Kyte JA (2024)
Peripheral immune cells in metastatic breast cancer patients display a systemic immunosuppressed signature consistent with chronic inflammation
NPJ Breast Cancer, 10 (1), 30
DOI 10.1038/s41523-024-00638-2, PubMed 38653982

Ørbo HS, Bjørlykke KH, Sexton J, Jyssum I, Tveter AT, Christensen IE, Mjaaland S, Kvien TK, Grødeland G, Kro GB, Jahnsen J, Haavardsholm EA, Munthe LA, Provan SA, Vaage JT, Goll GL, Jørgensen KK, Syversen SW (2024)
Incidence and outcome of COVID-19 following vaccine and hybrid immunity in patients on immunosuppressive therapy: identification of protective post-immunisation anti-RBD antibody levels in a prospective cohort study
RMD Open, 10 (2)
DOI 10.1136/rmdopen-2023-003545, PubMed 38599653

Małecka A, Østlie I, Trøen G, Małecki J, Delabie J, Tierens A, Munthe LA, Berentsen S, Tjønnfjord GE (2024)
Gene expression analysis revealed downregulation of complement receptor 1 in clonal B cells in cold agglutinin disease
Clin Exp Immunol, 216 (1), 45-54
DOI 10.1093/cei/uxad135, PubMed 38133636

Foss S, Sakya SA, Aguinagalde L, Lustig M, Shaughnessy J, Cruz AR, Scheepmaker L, Mathiesen L, Ruso-Julve F, Anthi AK, Gjølberg TT, Mester S, Bern M, Evers M, Bratlie DB, Michaelsen TE, Schlothauer T, Sok D, Bhattacharya J, Leusen J, Valerius T, Ram S, Rooijakkers SHM, Sandlie I, Andersen JT (2024)
Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria
Nat Commun, 15 (1), 2007
DOI 10.1038/s41467-024-46321-9, PubMed 38453922

Kared H, Jyssum I, Alirezaylavasani A, Egner IM, The Tran T, Tietze L, Lund KP, Tveter AT, Provan SA, Ørbo H, Haavardsholm EA, Vaage JT, Jørgensen K, Syversen SW, Lund-Johansen F, Goll GL, Munthe LA (2024)
Dynamics of SARS-CoV-2 immunity after vaccination and breakthrough infection in rituximab-treated rheumatoid arthritis patients: a prospective cohort study
Front Immunol, 15, 1296273
DOI 10.3389/fimmu.2024.1296273, PubMed 38455062

Federico L, Malone B, Tennøe S, Chaban V, Osen JR, Gainullin M, Smorodina E, Kared H, Akbar R, Greiff V, Stratford R, Clancy T, Munthe LA (2024)
Corrigendum: Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence
Front Immunol, 15, 1377041
DOI 10.3389/fimmu.2024.1377041, PubMed 38449865

Fein JA, Shouval R, Krieger E, Spellman SR, Wang T, Baldauf H, Fleischhauer K, Kröger N, Horowitz M, Maiers M, Miller JS, Mohty M, Nagler A, Weisdorf D, Malmberg KJ, Toor AA, Schetelig J, Romee R, Koreth J (2024)
Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML
Blood Adv, 8 (3), 581-590
DOI 10.1182/bloodadvances.2023011622, PubMed 38052043

Heinzelbecker J, Fauskanger M, Jonson I, Krengel U, Løset GÅ, Munthe L, Tveita A (2024)
Chimeric antigen receptor T cells targeting the GM3(Neu5Gc) ganglioside
Front Immunol, 15, 1331345
DOI 10.3389/fimmu.2024.1331345, PubMed 38370401

Gainullin M, Federico L, Røkke Osen J, Chaban V, Kared H, Alirezaylavasani A, Lund-Johansen F, Wildendahl G, Jacobsen JA, Sarwar Anjum H, Stratford R, Tennøe S, Malone B, Clancy T, Vaage JT, Henriksen K, Wüsthoff L, Munthe LA (2024)
People who use drugs show no increase in pre-existing T-cell cross-reactivity toward SARS-CoV-2 but develop a normal polyfunctional T-cell response after standard mRNA vaccination
Front Immunol, 14, 1235210
DOI 10.3389/fimmu.2023.1235210, PubMed 38299149

Podgorica M, Drivet E, Viken JK, Richman A, Vestbøstad J, Szodoray P, Kvam AK, Wik HS, Tjønnfjord GE, Munthe LA, Frietze S, Schjerven H (2024)
Transcriptome analysis of primary adult B-cell lineage acute lymphoblastic leukemia identifies pathogenic variants and gene fusions, and predicts subtypes for in depth molecular diagnosis
Eur J Haematol, 112 (5), 731-742
DOI 10.1111/ejh.14164, PubMed 38192186

Akshay A, Katoch M, Shekarchizadeh N, Abedi M, Sharma A, Burkhard FC, Adam RM, Monastyrskaya K, Gheinani AH (2024)
Machine Learning Made Easy (MLme): a comprehensive toolkit for machine learning-driven data analysis
Gigascience, 13
DOI 10.1093/gigascience/giad111, PubMed 38206587

Reusch J, Andersen JT, Rant U, Schlothauer T (2024)
Insight into the avidity-affinity relationship of the bivalent, pH-dependent interaction between IgG and FcRn
MAbs, 16 (1), 2361585
DOI 10.1080/19420862.2024.2361585, PubMed 38849969

Publications 2023

Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K, Myklebust JH (2023)
Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma
Blood Adv, 7 (23), 7216-7230
DOI 10.1182/bloodadvances.2023010158, PubMed 37695745

Tulika T, Pedersen RW, Rimbault C, Ahmadi S, Rivera-de-Torre E, Fernández-Quintero ML, Loeffler JR, Bohn MF, Ljungars A, Ledsgaard L, Voldborg BG, Ruso-Julve F, Andersen JT, Laustsen AH (2023)
Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library
Protein Sci, 32 (12), e4821
DOI 10.1002/pro.4821, PubMed 37897425

Benjakul S, Anthi AK, Kolderup A, Vaysburd M, Lode HE, Mallery D, Fossum E, Vikse EL, Albecka A, Ianevski A, Kainov D, Karlsen KF, Sakya SA, Nyquist-Andersen M, Gjølberg TT, Moe MC, Bjørås M, Sandlie I, James LC, Andersen JT (2023)
A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery
PNAS Nexus, 2 (12), pgad403
DOI 10.1093/pnasnexus/pgad403, PubMed 38077689

Federico L, Malone B, Tennøe S, Chaban V, Osen JR, Gainullin M, Smorodina E, Kared H, Akbar R, Greiff V, Stratford R, Clancy T, Munthe LA (2023)
Experimental validation of immunogenic SARS-CoV-2 T cell epitopes identified by artificial intelligence
Front Immunol, 14, 1265044
DOI 10.3389/fimmu.2023.1265044, PubMed 38045681

Jørstad ØK, Foss S, Gjølberg TT, Mester S, Nyquist-Andersen M, Sivertsen MS, Fossum D, Gleditsch E, Moe MC, Andersen JT (2023)
Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties
Int J Retina Vitreous, 9 (1), 65
DOI 10.1186/s40942-023-00507-3, PubMed 37936232

Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ (2023)
The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk
J Immunol, 211 (9), 1348-1358
DOI 10.4049/jimmunol.2300406, PubMed 37737664

Kared H, Alirezaylavasani A, Lund KP, Chopra A, Tietze L, de Matos Kasahara T, Goll GL, Grødeland G, Kaarbø M, Reisæter AV, Hovd M, Heldal K, Vaage JT, Lund-Johansen F, Midtvedt K, Åsberg A, Munthe LA (2023)
Hybrid and SARS-CoV-2-vaccine immunity in kidney transplant recipients
EBioMedicine, 97, 104833
DOI 10.1016/j.ebiom.2023.104833, PubMed 37844534

Boyle EM, Blaney P, Stoeckle JH, Wang Y, Ghamlouch H, Gagler D, Braunstein M, Williams L, Tenenbaum A, Siegel A, Chen X, Varma G, Avigan J, Li A, Jinsi M, Kaminetzsky D, Arbini A, Montes L, Corre J, Rustad EH, Landgren O, Maura F, Walker BA, Bauer M, Bruno B, Tsirigos A, Davies FE, Morgan GJ (2023)
Multiomic Mapping of Acquired Chromosome 1 Copy-Number and Structural Variants to Identify Therapeutic Vulnerabilities in Multiple Myeloma
Clin Cancer Res, 29 (19), 3901-3913
DOI 10.1158/1078-0432.CCR-22-3209, PubMed 37449980

Giannakopoulou E, Lehander M, Virding Culleton S, Yang W, Li Y, Karpanen T, Yoshizato T, Rustad EH, Nielsen MM, Bollineni RC, Tran TT, Delic-Sarac M, Gjerdingen TJ, Douvlataniotis K, Laos M, Ali M, Hillen A, Mazzi S, Chin DWL, Mehta A, Holm JS, Bentzen AK, Bill M, Griffioen M, Gedde-Dahl T, Lehmann S, Jacobsen SEW, Woll PS, Olweus J (2023)
A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo
Nat Cancer, 4 (10), 1474-1490
DOI 10.1038/s43018-023-00642-8, PubMed 37783807

Sandoz PA, Kuhnigk K, Szabo EK, Thunberg S, Erikson E, Sandström N, Verron Q, Brech A, Watzl C, Wagner AK, Alici E, Malmberg KJ, Uhlin M, Önfelt B (2023)
Modulation of lytic molecules restrain serial killing in γδ T lymphocytes
Nat Commun, 14 (1), 6035
DOI 10.1038/s41467-023-41634-7, PubMed 37758698

Lachota M, Zielniok K, Palacios D, Kanaya M, Penna L, Hoel HJ, Wiiger MT, Kveberg L, Hautz W, Zagożdżon R, Malmberg KJ (2023)
Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation
EBioMedicine, 96, 104811
DOI 10.1016/j.ebiom.2023.104811, PubMed 37741009

Giang KA, Boxaspen T, Diao Y, Nilvebrant J, Kosugi-Kanaya M, Kanaya M, Krokeide SZ, Lehmann F, Svensson Gelius S, Malmberg KJ, Nygren PÅ (2023)
Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells
N Biotechnol, 77, 139-148
DOI 10.1016/j.nbt.2023.09.002, PubMed 37673373

Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, Önfelt B, Norman PJ, Malmberg KJ (2023)
Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires
Blood Adv, 7 (16), 4492-4504
DOI 10.1182/bloodadvances.2023009827, PubMed 37327114

Foldvari Z, Knetter C, Yang W, Gjerdingen TJ, Bollineni RC, Tran TT, Lund-Johansen F, Kolstad A, Drousch K, Klopfleisch R, Leisegang M, Olweus J (2023)
A systematic safety pipeline for selection of T-cell receptors to enter clinical use
NPJ Vaccines, 8 (1), 126
DOI 10.1038/s41541-023-00713-y, PubMed 37607971

Federico L, Tvedt THA, Gainullin M, Osen JR, Chaban V, Lund KP, Tietze L, Tran TT, Lund-Johansen F, Kared H, Lind A, Vaage JT, Stratford R, Tennøe S, Malone B, Clancy T, Myhre AEL, Gedde-Dahl T, Munthe LA (2023)
Robust spike-specific CD4⁺ and CD8⁺ T cell responses in SARS-CoV-2 vaccinated hematopoietic cell transplantation recipients: a prospective, cohort study
Front Immunol, 14, 1210899
DOI 10.3389/fimmu.2023.1210899, PubMed 37503339

Casey NP, Klee CH, Fåne A, Caulier B, Graczyk-Jarzynka A, Krawczyk M, Fidyt K, Josefsson SE, Köksal H, Dillard P, Patkowska E, Firczuk M, Smeland EB, Winiarska M, Myklebust JH, Inderberg EM, Wälchli S (2023)
Efficient chimeric antigen receptor targeting of a central epitope of CD22
J Biol Chem, 299 (7), 104883
DOI 10.1016/j.jbc.2023.104883, PubMed 37269947

Vahid MR, Brown EL, Steen CB, Zhang W, Jeon HS, Kang M, Gentles AJ, Newman AM (2023)
High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE
Nat Biotechnol, 41 (11), 1543-1548
DOI 10.1038/s41587-023-01697-9, PubMed 36879008

Fernández-Quintero ML, Ljungars A, Waibl F, Greiff V, Andersen JT, Gjølberg TT, Jenkins TP, Voldborg BG, Grav LM, Kumar S, Georges G, Kettenberger H, Liedl KR, Tessier PM, McCafferty J, Laustsen AH (2023)
Assessing developability early in the discovery process for novel biologics
MAbs, 15 (1), 2171248
DOI 10.1080/19420862.2023.2171248, PubMed 36823021