Publications

Publications from PRIMA

Foss, S., Sakya, S.A., Aguinagalde, L. et al. Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria. Nat Commun 15, 2007 (2024).doi: 10.1038/s41467-024-46321-9

Tulika T, Pedersen RW, Rimbault C, Ahmadi S, Rivera-de-Torre E, Fernández-Quintero ML, Loeffler JR, Bohn MF, Ljungars A, Ledsgaard L, Voldborg BG, Ruso-Julve F, Andersen JT, Laustsen AH. Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library. Protein Sci. 2023 Dec;32(12):e4821. doi: 10.1002/pro.4821.

Benjakul S, Anthi AK, Kolderup A, Vaysburd M, Lode HE, Mallery D, Fossum E, Vikse EL, Albecka A, Ianevski A, Kainov D, Karlsen KF, Sakya SA, Nyquist-Andersen M, Gjølberg TT, Moe MC, Bjørås M, Sandlie I, James LC, Andersen JT. A pan-SARS-CoV-2-specific soluble angiotensin-converting enzyme 2-albumin fusion engineered for enhanced plasma half-life and needle-free mucosal delivery. PNAS Nexus. 2023 Nov 28;2(12):pgad403. doi: 10.1093/pnasnexus/pgad403

Jørstad ØK, Foss S, Gjølberg TT, Mester S, Nyquist-Andersen M, Sivertsen MS, Fossum D, Gleditsch E, Moe MC, Andersen JT. Pharmaceutical compounding and storage of faricimab in a syringe for intravitreal injection do not impair stability and bi-specific binding properties. Int J Retina Vitreous. 2023 Nov 7;9(1):65. doi: 10.1186/s40942-023-00507-3.

Spasevska I, Sharma A, Steen CB, Josefsson SE, Blaker YN, Kolstad A, Rustad EH, Meyer S, Isaksen K, Chellappa S, Kushekhar K, Beiske K, Førsund MS, Spetalen S, Holte H, Østenstad B, Brodtkorb M, Kimby E, Olweus J, Taskén K, Newman AM, Lorenz S, Smeland EB, Alizadeh AA, Huse K, Myklebust JH. Diversity of intratumoral regulatory T cells in B-cell non-Hodgkin lymphoma. Blood Adv. 2023 Dec 12;7(23):7216-7230. doi: 10.1182/bloodadvances.2023010158

Giang KA, Boxaspen T, Diao Y, Nilvebrant J, Kosugi-Kanaya M, Kanaya M, Krokeide SZ, Lehmann F, Svensson Gelius S, Malmberg KJ, Nygren PÅ. Affibody-based hBCMA x CD16 dual engagers for NK cell-mediated killing of multiple myeloma cells. N Biotechnol. 2023 Nov 25;77:139-148. doi:10.1016/j.nbt.2023.09.002.

Giannakopoulou E, Lehander M, Virding Culleton S, Yang W, Li Y, Karpanen T, Yoshizato T, Rustad EH, Nielsen MM, Bollineni RC, Tran TT, Delic-Sarac M, Gjerdingen TJ, Douvlataniotis K, Laos M, Ali M, Hillen A, Mazzi S, Chin DWL, Mehta A, Holm JS, Bentzen AK, Bill M, Griffioen M, Gedde-Dahl T, Lehmann S, Jacobsen SEW, Woll PS, Olweus J. A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo. Nat Cancer. 2023 Oct 2. doi: 10.1038/s43018-023-00642-8.

Sandoz PA, Kuhnigk K, Szabo EK, Thunberg S, Erikson E, Sandström N, Verron Q, Brech A, Watzl C, Wagner AK, Alici E, Malmberg KJ, Uhlin M, Önfelt B. Modulation of lytic molecules restrain serial killing in γδ T lymphocytes. Nat Commun. 2023 Sep 27;14(1):6035. doi: 10.1038/s41467-023-41634-7.

Clement D, Szabo EK, Krokeide SZ, Wiiger MT, Vincenti M, Palacios D, Chang YT, Grimm C, Patel S, Stenmark H, Brech A, Majhi RK, Malmberg KJ. The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk. J Immunol. 2023 Sep 22:ji2300406. doi: 10.4049/jimmunol.2300406.

Lachota M, Zielniok K, Palacios D, Kanaya M, Peena L, Hoel HJ, Wiiger MT, Kveberg L, Hautz W, Zagożdżon R, Malmberg KJ. Mapping the chemotactic landscape in NK cells reveals subset-specific synergistic migratory responses to dual chemokine receptor ligation. EBioMedicine. 2023 Sep 21;96:104811. doi: 10.1016/j.ebiom.2023.104811.

Foldvari Z, Knetter C, Yang W, Gjerdingen TJ, Bollineni RC, Tran TT, Lund- Johansen F, Kolstad A, Drousch K, Klopfleisch R, Leisegang M, Olweus J. A systematic safety pipeline for selection of T-cell receptors to enter clinical use. NPJ Vaccines. 2023 Aug 22;8(1):126. doi: 10.1038/s41541-023-00713-y.

Philippon C, Tao S, Clement D, Haroun-Izquierdo A, Kichula KM, Netskar H, Brandt L, Oei VS, Kanaya M, Lanuza PM, Schaffer M, Goodridge JP, Horowitz A, Zhu F, Hammer Q, Sohlberg E, Majhi RK, Kveberg L, Önfelt B, Norman PJ, Malmberg KJ. Allelic variation of KIR and HLA tunes the cytolytic payload and determines functional hierarchy of NK cell repertoires. Blood Adv. 2023 Aug 22;7(16):4492-4504. doi: 10.1182/bloodadvances.2023009827.

Casey NP, Klee CH, Fåne A, Caulier B, Graczyk-Jarzynka A, Krawczyk M, Fidyt K, Josefsson SE, Köksal H, Dillard P, Patkowska E, Firczuk M, Smeland EB, Winiarska M, Myklebust JH, Inderberg EM, Wälchli S. Efficient chimeric antigen receptor targeting of a central epitope of CD22. J Biol Chem. 2023 Jul;299(7):104883. doi: 10.1016/j.jbc.2023.104883.

Selected publications pre PRIMA

Gjølberg, T.T., Wik, J.A., Johannessen, H. et al. Antibody blockade of Jagged1 attenuates choroidal neovascularization. Nat Commun 14, 3109 (2023). https://doi.org/10.1038/s41467-023-38563-w

Philippon, C., Tao, S.A., Clement, D., et al. Allelic Variation of KIR and HLA Tunes the Cytolytic Payload and Determines Functional Hierarchy of NK Cell Repertoires. Blood Adv 2023; bloodadvances.2023009827. https://doi.org/10.1182/bloodadvances.2023009827

Hermansen, J.U., Yin, Y., Urban, A. et al. A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine. Cell Death Discov. 9, 125 (2023). https://doi.org/10.1038/s41420-023-01426-w

Mukadam, A.S., et al. Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models. Science379,1336-1341(2023). https://doi.org/10.1126/science.abn1366

Casey, N.P, Klee, C.H., Fåne, A., et al. Efficient chimeric antigen receptor (CAR) targeting of a central epitope of CD22. Journal of Biological Chemistry, 104883 (2023) https://doi.org/10.1016/j.jbc.2023.104883

Fernández-Quintero, M-L-, Ljungars, A., Waibl, F., et al. Assessing developability early in the discovery process for novel biologics, mAbs, 15:1 (2023). https://doi.org/10.1080/19420862.2023.2171248

Foss S, Jonsson A, Bottermann M et al. Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge. Sci. Immunol.7,eabj1640 (2022). https://doi.org/10.1126/sciimmunol.abj1640

Pataskar, A., Champagne, J., Nagel, R. et al. Tryptophan depletion results in tryptophan-to-phenylalanine substitutants. Nature 603, 721–727 (2022). https://doi.org/10.1038/s41586-022-04499-2

Ali, M., Giannakopoulou, E., Li, Y. et al. T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Nat Biotechnol 40, 488–498 (2022). https://doi.org/10.1038/s41587-021-01089-x

Cichocki, F., Bjordahl, R., Goodridge, J.P. et al. Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma. Nat Commun 13, 7341 (2022). https://doi.org/10.1038/s41467-022-35127-2

Bollineni, R.C., Tran, T.T, Lund-Johansen, F., et al. Chasing neoantigens; invite naïve T cells to the party. Current Opinion in Immunology, Volume 75, 102172 (2022). https://doi.org/10.1016/j.coi.2022.102172

Haroun-Izquierdo A, Vincenti M, Netskar H, et alAdaptive single-KIR+NKG2C+ NK cells expanded from select superdonors show potent missing-self reactivity and efficiently control HLA-mismatched acute myeloid leukemia. Journal for ImmunoTherapy of Cancer 2022;10:e005577. https://doi.org/10.1136/jitc-2022-005577

Robert, P.A., Akbar, R., Frank, R. et al. Unconstrained generation of synthetic antibody–antigen structures to guide machine learning methodology for antibody specificity prediction. Nat Comput Sci 2, 845–865 (2022). https://doi.org/10.1038/s43588-022-00372-4

Salomé B., Sfakianos JP, Ranti D., et al. NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer. Cancer Cell, 40(9) (2022). https://doi.org/10.1016/j.ccell.2022.08.005

Grevys, A., Frick, R., Mester, S.,et al. Antibody variable sequences have a pronounced effect on cellular transport and plasma half-life. iScience, Volume 25, Issue 2 (2022). https://doi.org/10.1016/j.isci.2022.103746

Rye, I.H., Huse, K., Josefsson, S.E., Kildal, W., et al. Breast cancer metastasis: immune profiling of lymph nodes reveals exhaustion of effector T cells and immunosuppression. Mol Oncol, 16: 88-103 (2022). https://doi.org/10.1002/1878-0261.13047

Giliberto, M., Thimiri Govinda Raj, D.B., Cremaschi, A., et al. Ex vivo drug sensitivity screening in multiple myeloma identifies drug combinations that act synergistically. Mol Oncol, 16: 1241-1258 (2022). https://doi.org/10.1002/1878-0261.13191

Shapiro RM, Birch GC, Hu G. et al. Expansion, persistence, and efficacy of donor memory-like NK cells infused for posttransplant relapse. J Clin Invest. 2022;132(11):e154334 (2022). https://doi.org/10.1172/JCI154334

Skånland SS, Inngjerdingen M, Bendiksen H, et al. Functional testing of relapsed chronic lymphocytic leukemia guides precision medicine and maps response and resistance mechanisms. An index case. Haematologica 2022;107(8):1994-1998; https://doi.org/10.3324/haematol.2021.280393.

Akbar, R., Bashour, H., Rawat, P., et al. Progress and challenges for the machine learning-based design of fit-for-purpose monoclonal antibodies, mAbs, 14:1, (2022) https://doi.org/10.1080/19420862.2021.2008790

Minton AR, Smith LD, Bryant DJ, Strefford JC, Forconi F, Stevenson FK, et al. B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells. Explor Target Antitumor Ther. 2022;3:37–49. https://doi.org/10.37349/etat.2022.00070

Imbery, JF, Heinzelbecker, J, Jebsen, JK, McGowan, M, Myklebust, C, Bottini, N, et al. T-helper cell regulation of CD45 phosphatase activity by galectin-1 and CD43 governs chronic lymphocytic leukaemia proliferation. Br J Haematol. 2022; 198: 556– 573. https://doi.org/10.1111/bjh.18285

Sandvei, M.S., Jacobsen, G.W., Stien, M.H., et al. A national intercalated medical student research program – student perceptions, satisfaction, and factors associated with pursuing a PhD, Medical Education Online, 27:1 (2022) https://doi.org/10.1080/10872981.2022.2122105

Bartok, O., Pataskar, A., Nagel, R. et al. Anti-tumour immunity induces aberrant peptide presentation in melanoma. Nature 590, 332–337 (2021). https://doi.org/10.1038/s41586-020-03054-1

Lund-Johansen, F., Tran, T. & Mehta, A. Towards reproducibility in large-scale analysis of protein–protein interactions. Nat Methods 18, 720–721 (2021). https://doi.org/10.1038/s41592-021-01202-7

Woan, KV, et al. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell (2021). https://doi.org/10.1016/j.stem.2021.08.013

Luca, BA, Steen, CB, et al. Atlas of clinically distinct cell states and ecosystems across human solid tumors. Cell 184, 5482-5496 e5428 (2021). https://doi.org/10.1016/j.cell.2021.09.014

Steen, CB, Luca, B.A., Esfahani, M.S., et al. The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma. Cancer Cell 39, 1422-1437 e1410 (2021). https://doi.org/10.1016/j.ccell.2021.08.011

Ask, EH, Tschan-Plessl, A., Gjerdingen, T.J., et al. A systemic protein deviation score linked to PD-1+CD8+T cell expansion that predicts overall survival in diffuse large B cell lymphoma. Med 1, 180-195 (2021). https://doi.org/10.1016/j.medj.2020.10.006

Szodoray, P., Andersen, T.K., Heinzelbecker, J., et al. Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity. Cell Reports, 36 (6), (2021). https://doi.org/10.1016/j.celrep.2021.109525

Bern, M, Nilsen J., Ferrarese, M., et al. An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics. Sci Transl Med 12 (2020). https://doi.org/10.1126/scitranslmed.abb0580

Wise, J.F., Nakken, S., Steen, C.B. et al. Mutational dynamics and immune evasion in diffuse large B-cell lymphoma explored in a relapse-enriched patient series. Blood Adv 2020; 4 (9): 1859–1866. https://doi.org/10.1182/bloodadvances.2019001325

Majzner RG, Rietberg SP, Sotillo E, et al. Tuning the Antigen Density Requirement for CAR T-cell Activity. Cancer Discov. 2020 May;10(5):702-723. https://doi.org/10.1158/2159-8290.CD-19-094

Shaw, A., Hoffecker, I.T., Smyrlaki, I. et al. Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies. Nature Nanotech 14, 184–190 (2019). https://doi.org/10.1038/s41565-018-0336-3

Saetersmoen, M.L., Hammer, Q., Valamehr, B. et al. Off-the-shelf cell therapy with induced pluripotent stem cell-derived natural killer cells. Semin Immunopathol 41, 59–68 (2019). https://doi.org/10.1007/s00281-018-0721-x

Ali, M., Foldvari, Z., Giannakopoulou, E. et al. Induction of neoantigen-reactive T cells from healthy donors. Nat Protoc 14, 1926–1943 (2019). https://doi.org/10.1038/s41596-019-0170-6

Sikorski, K., Mehta, A., Inngjerdingen, M. et al. A high-throughput pipeline for validation of antibodies. Nat Methods 15, 909–912 (2018). https://doi.org/10.1038/s41592-018-0179-8

Bjorklund, A. T. et al. Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. Clin Cancer Res 24, 1834-1844, (2018). https://doi.org/10.1158/1078-0432.CCR-17-3196

Haapaniemi, E., Botla, S., Persson, J., et al. CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response. Nat Med 24, 927-930 (2018). https://doi.org/10.1038/s41591-018-0049-z

Grevys, A., Nilsen, J., Sand, K.M., et al. A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nat Commun 9, 621 (2018). https://doi.org/10.1038/s41467-018-03061-x

Wang, D., Fløisand, Y., Myklebust, C. et al. Autologous bone marrow Th cells can support multiple myeloma cell proliferation in vitro and in xenografted mice. Leukemia 31, 2114–2121 (2017). https://doi.org/10.1038/leu.2017.69

Olweus, J. Manufacture of CAR-T cells in the body. Nat Biotechnol 35, 520–521 (2017). https://doi.org/10.1038/nbt.3898

Karpanen, T & Olweus, J. The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy. Front Immunol 8, 1718 (2017). https://doi.org/10.3389/fimmu.2017.01718

Stronen, E., Toebes, M., Kelderman, S., et al. Targeting of cancer neoantigens with donor-derived T cell receptor repertoires. Science 352, 1337-1341 (2016). https://doi.org/10.1126/science.aaf2288

Lund-Johansen, F., de la Rosa Carrillo, D., Mehta, A. et al. MetaMass, a tool for meta-analysis of subcellular proteomics data. Nat Methods 13, 837–840 (2016). https://doi.org/10.1038/nmeth.3967

Mensali, N., et al. Targeting B-cell neoplasia with T-cell receptors recognizing a CD20-derived peptide on patient-specific HLA. Oncoimmunology 5, e1138199, (2016). https://doi.org/10.1080/2162402X.2016.1138199

Kumari, S., et al. Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes. Proc Natl Acad Sci U S A 111, 403-408 (2014). https://doi.org/10.1073/pnas.1306549111

Published June 6, 2023 12:29 PM - Last modified Mar. 19, 2024 1:57 PM