Goal of the project
Employ cutting-edge technologies on paired healthy and malignant prostate tissues to understand how cellular interactions between the tumor microenvironment (TME) and resident memory T cells (TRM) may impact the phenotype and function of tumor-infiltrating lymphocytes (TILs).
Status update
We are in the process of establishing a comprehensive biobank of prostate tissue samples which will be analyzed with spectral flow cytometry and imaging mass cytometry. Currently we are validating our methods on control samples.
Grant details
- Awardee: Hassen Kared, researcher, Munthe group
- PRIMA Synergy Grant (03): 200 000 NOK
- Title of the project: Mapping T Cell subsets and TME types in Prostate Cancer
- Collaborative groups: Munthe and Myklebust
- Other project participants: Ivana Spasevska, Kanutte Huse, Colin LaMont, and PIs Ludvig Munthe and June H Myklebust
What you think of the Synergy grant mechanism?
The procedure was pretty straightforward and fast. This grant encourages us to contact other scientists to initiate collaborations. Applying to this grant enabled us to get out of our comfort zone and test hypotheses with new angles, perspectives, and techniques.